000			01810nam a22002297i 4500
008			230812s2012 |||a|||| |||| 001 0 eng d
020			_a9781849731928 _qhbk.
040			_aGCL
082			_a615.19 _bPAL
245	1	0	_aNeglected diseases and drug discovery / _cMichael J. Palmer, Timothy N. C. Wells.
260			_aCambridge : _bRoyal Society of Chemistry, _c2012.
300			_axix, 438 pages : _billustrations ; _c24 cm.
336			_atext _btxt _2rdacontent
337			_aunmediated _bn _2rdamedia
338			_avolume _bnc _2rdacarrier
500			_aIncludes index.
520			_aThere are about 8 million deaths each year from neglected tropical diseases (NTDs) in the underdeveloped world, whilst drug discovery focus and practice is only recently taking on greater urgency and embracing the latest technologies. This unique book is a state of the art review of drug discovery in respect of NTDs and highlights best practice to guide the ongoing drug discovery effort and also to raise debate and awareness in areas that remain highly neglected. All the major diseases such as malaria, trypanosomatids and TB are covered, with a review of each disease and established compounds, new mechanistic classes and new horizons. Each chapter highlights the key science that has led to breakthroughs, with detailed assessment of the key medicinal chemistry involved, and critical appraisal of new emerging approaches. Later chapters highlight under publicized disease areas where the medical needs are neglected and research is very limited, to raise awareness. The editors, acknowledged experts in the field, have a wealth of experience in successful drug discovery practice and tropical diseases.
650			_aChemistry
700	1	0	_aPalmer, Michael J.
700	1	0	_aWells, Timothy N. C.
942			_2ddc
999			_c1114 _d1114