02250nam a22002417i 4500 230812s2012 |||a|||| |||| 001 0 eng d 9781849731904 hbk. GCL 615.19 WOS Polyamine drug discovery / Patrick M. Woster, Robert Anthony Casero, Royal Society of Chemistry (Great Britain). Cambridge : Royal Society of Chemistry, 2012. xii, 289 pages : illustrations ; 24 cm. text txt rdacontent unmediated n rdamedia volume nc rdacarrier Includes index. Polyamines are ubiquitous molecules that are involved in a number of important cellular processes. Aberrations in their function or metabolism play a role in diseases such as cancer and parasitic infection. A number of validated drug targets have been identified, including enzymes in the polyamine biosynthetic and catabolic pathways and the S-adenosylmethionine synthetic and salvage pathways. Polyamine Drug Discovery is the first comprehensive volume to cover all aspects of the design and development of potential therapeutics targeting polyamine metabolism. The book details research progress from 1975 to the present date and discusses the design and use of polyamine metabolism inhibitors as therapeutic agents. Various polyamine-containing drugs are described that can be used in chemotherapy, and as treatments for infections including trypanosomiasis, leishmaniasis and malaria. Finally, the roles of polyamine analogues in chemoprevention, polyamine-containing vectors for gene delivery, and the design of polyamine-based epigenetic modulators are detailed. Each chapter addresses a different aspect of polyamine drug discovery and all are written by medicinal and biological chemists with particular expertise in developing agents that modulate polyamine metabolism or function. The book will increase the visibility of polyamine drug discovery among pharmaceutical researchers and provide a valuable reference for everyone working in the field Chemistry Woster, Patrick M. Casero, Robert Anthony Royal Society of Chemistry (Great Britain) ddc 0 0 ddc 0 615_190000000000000_WOS 0 1761 LPL LPL 2023-08-12 0 615.19 WOS 15560 2023-08-12 00:00:00 2023-08-12 BK 1111 1111