Polyamine drug discovery / (Record no. 1111)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02250nam a22002417i 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 230812s2012 |||a|||| |||| 001 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781849731904 |
| Qualifying information | hbk. |
| 040 ## - Cataloging Source | |
| Original cataloging agency | GCL |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.19 |
| Item number | WOS |
| 245 ## - TITLE STATEMENT | |
| Title | Polyamine drug discovery / |
| Statement of responsibility, etc. | Patrick M. Woster, Robert Anthony Casero, Royal Society of Chemistry (Great Britain). |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cambridge : |
| Name of publisher, distributor, etc. | Royal Society of Chemistry, |
| Date of publication, distribution, etc. | 2012. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | xii, 289 pages : |
| Other physical details | illustrations ; |
| Dimensions | 24 cm. |
| 336 ## - Content Type | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - Media Type | |
| Media type term | unmediated |
| Media type code | n |
| Source | rdamedia |
| 338 ## - Carrier Type | |
| Carrier type term | volume |
| Carrier type code | nc |
| Source | rdacarrier |
| 500 ## - GENERAL NOTE | |
| General note | Includes index. |
| 520 ## - Summary, etc. | |
| Summary, etc. | Polyamines are ubiquitous molecules that are involved in a number of important cellular processes. Aberrations in their function or metabolism play a role in diseases such as cancer and parasitic infection. A number of validated drug targets have been identified, including enzymes in the polyamine biosynthetic and catabolic pathways and the S-adenosylmethionine synthetic and salvage pathways. Polyamine Drug Discovery is the first comprehensive volume to cover all aspects of the design and development of potential therapeutics targeting polyamine metabolism. The book details research progress from 1975 to the present date and discusses the design and use of polyamine metabolism inhibitors as therapeutic agents. Various polyamine-containing drugs are described that can be used in chemotherapy, and as treatments for infections including trypanosomiasis, leishmaniasis and malaria. Finally, the roles of polyamine analogues in chemoprevention, polyamine-containing vectors for gene delivery, and the design of polyamine-based epigenetic modulators are detailed. Each chapter addresses a different aspect of polyamine drug discovery and all are written by medicinal and biological chemists with particular expertise in developing agents that modulate polyamine metabolism or function. The book will increase the visibility of polyamine drug discovery among pharmaceutical researchers and provide a valuable reference for everyone working in the field<br/> |
| 650 ## - Subject Added Entry - Topical Term | |
| Topical term | Chemistry |
| 700 10 - Added Entry - Personal Name | |
| Personal name | Woster, Patrick M. |
| 700 10 - Added Entry - Personal Name | |
| Personal name | Casero, Robert Anthony |
| 710 2# - Added Entry - Corporate Name | |
| Corporate name or jurisdiction name as entry element | Royal Society of Chemistry (Great Britain) |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Date acquired | Total checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | Govt. Graduate College Gulberg, Lahore - Central Library | Govt. Graduate College Gulberg, Lahore - Central Library | 12/08/2023 | 615.19 WOS | 15560 | 12/08/2023 | 12/08/2023 | Books |